Articular Cartilage Defect Treatment

DeNovo® NT Graft is a particulated juvenile cartilage implant utilized for the repair of articular cartilage damage. A more detailed examination of the information was made using the cartilage thickness and compressive modulus data of every single individual indentation test site from a joint surface, as shown in figures 4 B, 4 C, and 4 D. Once again the data confirm a great inverse relation between the cartilage thickness and its compressive modulus. While the low p values reveal significance, the relatively low r values indicate a high scatter in the data.
Microfracture is an appealing option in the remedying of articular the fibrous connective tissue cartilage injury because it is relatively basic with minimal morbidity. It appears best suited intended for young patients with severe, smaller contained lesions. 68 collaflex lek Potential deterioration of medical results over time may be related to defect repair with hyaline-like” rather than true hyaline cartilage, with resultant compromise in wear characteristics. This has motivated investigation toward replacement and remodeling techniques.
The slim superficial (tangential) zone shields deeper layers from shear stresses and makes up approximately 10% to even just the teens of articular cartilage density. The collagen fibers of this zone (primarily, type II and IX collagen) are packed tightly and aligned parallel to the articular surface ( Figure 2 ). The superficial layer contains a large number of flattened chondrocytes, and the integrity of this layer is crucial in the protection and maintenance of deeper levels. This zone is in connection with synovial fluid and is responsible for most of the tensile properties of cartilage, which enable that to resist the sheer, tensile, and compressive forces imposed by articulation.
Classification performance with 3D bSSFP imaging is similar to that with standard SECOND sequences and commonly used 3D GRE sequences intended for the morphologic assessment of knee cartilage ( twenty two, 42 ) ( Fig 13 ). The approach also is useful for image resolution other internal structures of the knee, such because ligaments and menisci ( 43 ), a capacity that makes it an attractive option for clinical practice.
The superficial collagen fibres are thin and closely are arranged parallel to the joint surface area and lie perpendicular to the principal axis of motion for a particular joint. They allow intended for near frictionless joint movement. Collagen fibres in the middle or transitional zone are more advanced in size and obliquely proteoglycans are trapped and contained within their construction The biggest collagen fibres in the deep or great zone are arranged verticle with respect to the joint sink into the calcified layer to enter the subchondral bone fragments and anchor the the fibrous connective tissue cartilage to the underlying bone.articular cartilage damage recovery time